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Parallel Solid Phase Synthesis

Solid Phase Synthesis
Solid phase synthesis is a technique where molecules are temporarily bound to an insoluble support in order to streamline the synthesis process. Advantages include easy removal of excess reactants and by products via washing and filtration. Applications include synthesis of peptides and pharmaceuticals. New synthetic methods for solid-phase synthesis are routinely developed. Parallel solid phase synthesis is a valuable alternative to traditional synthesis.

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Products and Solutions
Parallel Synthesis: MiniBlock® and MiniBlock® XT Particle System Characterization: FBRM® and PVM® Automated Lab Reactors (ALR) and Reaction Calorimeters: RC1e™ and EasyMax™ In situ FTIR Reaction Analysis: ReactIR™ Software: iC and iControl™
Applications
Emerging Technologies Supporting Chemical Process R&D and Their Increasing Impact on Productivity in the Pharmaceutical Industry
Construction of 6-Amino-2,2-Dimethyl-3,4,6-Trisubstituted-2H-1-Benzopyran Library by Solid Phase Synthesis
Uncompetitive Antagonism of AMPA Receptors: Mechanistic Insights from Studies of Polyamine Toxin Derivatives
Solid-Phase Synthesis of Tetrahydro-1,4-benzodiazepine-2-one Derivatives as a â-Turn Peptidomimetic Library
Method for the Solid-Phase Parallel Synthesis of a 6-Alkylamino-2-(functionalized-aminomethyl)-2H-1-benzopyran Library
Use of Quinolinium Salts in Parallel Synthesis for the Preparation of 4-Amino-2-alkyl-1,2,3,4-tetrahydroquinoline
Solid-phase Synthesis of sn-1,2- and sn-2,3-Diacylglycerols via Ring-Opening of the Glycidyl-Bound Resin
Solid-Phase Synthesis of 5-Amino-1-(Substituted Thiocarbamoyl)pyrazole and 1,2,4-Triazole Derivatives via Dithiocarbazate Linker
Modular Three-Component Solid-Phase Synthesis of Unsymmetrical Guanidines via Resin Capture of Carbodiimides
Parallel Synthesis of 3-Amino-4H-Quinolizin-4-ones, Fused 3-Amino-4H-Pyrimidin-4-ones, and Fused 3-Amino-2H-Pyran-2-ones
Alternative Solvents for Elevated-Temperature Solid-Phase Parallel Synthesis. Application to Thionation of Amides
Solid-Phase Synthesis of Urea and Amide Libraries Using the T2 Triazene Linker
Application of Lean Manufacturing Concepts to Drug Discovery: Rapid Analogue Library Synthesis
Parallel Solution-Phase Synthesis of (Z)-3-(Arylamino)-2,3-dehydroalanine Derivatives and Solid-Phase Synthesis of Fused Pyrimidones
Application of Solution-Phase Parallel Synthesis to Preparation of Trisubstituted 1,2,4-Triazoles
Combinatorial Synthesis of Substituted Biaryls and Heterocyclic Arylamines
Diverse 2-Carboxamide-3-amino-Substituted Quinoxalines: Synthesis and Reactivity Investigation for Library Generation
Solid Phase Synthesis using MiniBlock
Olefin Synthesis - Sub-Ambient Termperatures and Inert Atmosphere
Organometallic Reaction (pdf)