Highly reactive chemistry is used to describe chemical reactions that are particularly challenging due to the potentially hazardous and/or energetic nature of the reactants, intermediates and products that are present during synthesis. These chemistries often involve highly exothermic reactions which require specialized equipment or extreme (such as low temperature) operating conditions to ensure adequate control. Ensuring safe operating conditions, minimizing human exposure, and maximizing the information gained from each experiment are key factors in successfully designing and scaling up highly reactive chemistries.
Particularly challenging is the fact that sampling of the reactor contents during the reaction is often impractical or impossible under the desired operating conditions. In addition, as highly reactive materials are often unstable, the accuracy of any possible offline analysis is often limited.
Particularly challenging is the fact that sampling of the reactor contents during the reaction is often impractical or impossible under the desired operating conditions. In addition, as highly reactive materials are often unstable, the accuracy of any possible offline analysis is often limited.
These challenges can be immediately addressed through data rich experimentation using in situ reaction monitoring with ReactIRTM and RTCalTM real-time calorimetry in combination with accurately controlled automated lab reactors. These combined tools can be used to quickly and easily provide the information needed for safe and effective scale-up to pilot and production.
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