Lab to Plant Tools for Chemical Process Development
Automated synthesis workstations replace traditional round bottom flasks or jacketed lab reactors and allow synthetic organic chemists to explore new reaction conditions and develop innovative chemistry in an R&D environment. Engineers apply an advanced version of automated laboratory reactors (ALR) to measure real time reaction calorimetry and thermodynamic data for process safety understanding and control.
In situ reaction analysis with Attenuated Total Reflection (ATR) Fourier Transform Infrared (FTIR) spectroscopy provides real time monitoring of key reaction species. By following reaction progression, initiation, conversion, intermediate formation and endpoints, these tools optimize process design and quality. Increased process knowledge from inline reaction analysis supports the development of batch or continuous flow chemistry and enables chemical reactions to be scaled-up.
Inline particle size and shape analysis enables scientists and engineers to track the rate and degree of change to particles, crystals, or droplets as they naturally exist in process. By understanding how particles change in real time, engineers can track batch to batch consistency, detect endpoints, and optimize downstream throughput and product quality.
Inline Process Analytical Technologies (PAT) are probe-based instruments that track critical process parameters and quality attributes for Quality by Design (QbD) requirements. Lab PAT instruments help design a quality process. Plant PAT tools enable monitoring and control of a process.
Integrated software enables researchers to combine all technology in a simple and powerful platform, which captures data, visualizes and interprets experiments, prepares and report results, and compares batches or experiments.