METTLER TOLEDO
 

Fermentation and BioProcessing

Fermentation and BioProcessing

Characterize & Optimize BioProcess To Maximize Production & Isolation Of Desired End Product

New applications of Process Analytical Technology (PAT) offer direct measurement of critical process parameters and quality attributes in fermentation and bioprocessing - eliminating the need for offline sampling and analysis while providing real-time detection of process deviations and offering the ability for optimization and control of batch fermentation processes, applying biocatalysis to organic synthesis, peptide synthesis, protein and peptide crystallization scale-up.

Biotechnology has long been held as the key to our continued growth and prosperity. As we consider mankind’s greatest challenges – such as providing the food, medicine, and energy sources that will allow us to continue to improve the quality of life across a population that is growing in number and in age – it is increasingly biotechnology that appears capable of meeting these needs.


“The 20th century was shaped by spectacular breakthroughs in physics and chemistry, but the stars of the 21st century will be the biological sciences, and those deciphering the genetic code of life. “ Jeremy Rifkin, The Biotech Century: Genetic Commerce and the Dawn of a New Era


In addition, as the sustainability of our industrial practices gains importance, biotechnology plays a critical role in economically meeting the needs for renewable and sustainable sources of energy and materials. And, as more and more biotech processes are developed and scaled-up to full scale commercialization, the importance of an efficient and well-designed process to deliver sustainable and profitable bio-pharmaceuticals, bio-fuels and other bio-products becomes more and more evident.


METTLER TOLEDO has been a world leader in solutions and technologies for fermentation and biotechnology through the INGOLD line of pH, DO, conductivity, turbidity, and CO2 for process analytics applications. Yet bioprocesses, especially fermentations, are known to vary significantly from batch to batch as individual cell lines tend to be sensitive to their local growing conditions. So even with accurate measurement and control of the operating conditions, the growth of cell mass and the production rate of the target compound can still vary considerably – requiring additional off-line sampling and analysis to confirm the batch is operating within acceptable limits.