Optimization and scale-up of crystallization and precipitation to produce a product that consistently meets purity, yield, form and particle size specifications can be one of the biggest challenges of process development. The use of Process Analytical Technology (PAT) tools for real-time monitoring of the crystal distribution and population (using FBRM® and PVM®) and the supersaturation driving force (with ReactIR™) have simplified the understanding, optimization and control of crystallization. The integration of PAT tools with synthesis workstations ensures the precise monitoring and control of critical process variables and a more accurate determination of the acceptable and optimal design space for the crystallization step.
Crystallization White Papers
- Recent Advances for Seeding a Crystallization Process
- Best Practices for Crystallization Development
- A Guide to Scale-up of Batch Crystallization from Lab to Plant
- Advancing Beyond Turbidity: In Situ Monitoring and Control of Complex Particle and Droplet Systems
Popular Crystallization On-Demand Webinars
- Eliminating Micronization Using Fine Particle Crystallization
- Optimization and Scale-up of Anti-Solvent Addition Crystallization from Lab to Pilot Plant
- Top 5 High Impact Ways To Improve Laboratory Crystallization
- Calibration Free Supersaturation Assessment and Control for the Development and Optimization of Crystallization Processes
Crystallization Application Notes - Library for application notes and other crystallization resources
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