METTLER TOLEDO
 

Crystallization: from screening to optimization using smart lab reactors on-demand webinar

Crystallization is a critical step in the manufacturing processes of active pharmaceutical ingredients (APIs) in pharmaceutical or crop protection industries as well as in the chemical and fine chemical industries. The formation, growth, and quality of crystals are dependent on various factors, such as the crystal substance, solvent type, cooling profile, mixing conditions, and the type and design of the reactor.

Crystallization: from screening to optimization using smart lab reactors Webinar details
Development of a robust crystallization process can be used to simultaneously maximize yield, minimize impurities, and ensure a consistent particle size for formulations. This webinar will illustrate that understanding crystallization processes is essential for:

  • A consistent high quality final product
  • Reproducing size, shape, polymorphism, and purity of the crystals
  • Maximizing yield
  • Developing efficient production process more quickly
  • Saving time and money

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We will also demonstrate that by adding smart reactor technology,  from 50ml to 18L, to crystallization studies it will allow for a robust and scalable crystallization process via:
  • Accurate, advanced temperature measurement and control (non-linear cooling, temperature cycling)
  • Accurate and reproducible gravimetric or volumetric dosing control
  • Optimized reactor design for excellent mixing
  • Optimize suspension mixing - wide range of mixing setups available
  • Automated mixing studies
  • Accurate pH control for pH shift precipitations
  • Intelligent feedback control using  ReactIRTM and  Lasentec® FBRM®
  • Reactors with high ratio of starting volume to final volume
  • Flexible volume range (50ml to 18L) - ideal for scale-up