Supersaturation is a non-equilibrium state where there is more solute dissolved in solution than in the equilibrium state at a given temperature. A solute will remain in solution until there is a sufficient level of supersaturation to induce crystal formation. Supersaturation is the driving force for subsequent crystal nucleation and growth and impacts on the final crystal size distribution. By controlling supersaturation, target crystal size specifications may be achieved. Knowledge of the prevailing supersaturation level can also facilitate production of the correct polymorphic form. ATR-FTIR has emerged as a useful technique for the measurement of solution phase concentration, and when combined with accurate solubility data, supersaturation. ReactIR® is a probe-based technology that allows supersaturation to be monitored in situ and in real-time with no need for sampling. ReactIR® may be implemented at scales ranging from the lab, through the pilot plant and onto production. |  Click to see a preview |
Your online presenter, Des O’Grady, holds extensive experience in the implementation of Process Analytical Technology (PAT) technologies in crystallization design and development. Des completed his Ph.D. research involving the design and optimization of anti-solvent crystallization and is a member of our Technology & Application Consultant team.
This on-demand webinar aims to introduce the concept and importance of supersaturation measurement for crystallization optimization, development and scale-up. A number of crystallization case studies will be presented that highlight the value of utilizing ReactIR® in conjuction with other established crystallization measurement techniques such as FBRM® and PVM®.