Current practice requires the development of a robust crystallization using a minimal amount of Active Pharmaceutical Ingredient (API) product. Experiments are often not practical on a one litre or larger scale until the crystallization process is much further along in the development cycle. This Maximizing the Value of Crystallization Experiments on-demand webinar focuses on the type of crystallization experiments that can be performed at a small scale (< 50 mL) and how the FBRM® data generated can be used effectively in ensuring a robust process for scale-up through maximizing yield, optimizing the crystal size distribution and minimizing impurities. Maximizing the Value of Crystallization Experiments On-Demand Webinar Topics | ![]() Click to see a preview |
Case studies
A variety of Crystallization examples will be presented to illustrate the benefits and value of using this FBRM® technology including:
- Determination of solubility and metastable zone width along with experimental factors impacting the metastable zone
- Generation of crystallization kinetics
- Designing seeding protocol
- Design of an optimum cooling curve to minimize fine crystals and impurities
- Design of an optimum antisolvent addition rate
- Using the small scale reactor for "scale down" experiments

