Optimization of High Shear Wet Granulation Scale-up using FBRM® and PVM® on-demand webinar

One goal of high shear granulation is to yield a repeatable endpoint granule size and granule shape distribution. This is necessary for consistent downstream flow properties, tablet consistency, and content uniformity. However, inconsistencies often occur during granulation development and scale up due to changing raw materials, vessel-blade geometry, or process dynamics such as segregation and over wetting.

Webinar Details
The application of in situ particle characterization techniques, Focused Beam Reflectance Measurement [FBRM®] and Particle Video Microscopy [PVM®] is demonstrated to track a series of high shear wet granulation batches between 6 liter and 75 liters while varying liquid addition, spray rate, and wet massing time. Design of experiment (DOE) results are presented including the implementation of feedback control to achieve a specific target endpoint distribution and optimized wet massing time.

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FBRM® enables formulators and engineers to monitor real-time changes in particle count and dimension during cohesive wet or dry particle processing. In situ measurements enable Quality by Design (QbD) to minimize batch failures, improve yield, and troubleshoot scale-up to manufacturing. This allows for faster understanding and optimization of a formulation with no sampling required.

Ensure Consistent Measurements
The new, innovative FBRM® C35 addresses applications where window fouling is a potential issue. A patented scraper keeps the FBRM® probe window clean allowing the system to track particle agglomeration, compaction, and breakage even in the most cohesive particle conditions.