Real-Time In Situ FTIR with ReactIR as a Complementary Tool to HPLC - METTLER TOLEDO

Traditionally, organic chemists have relied mainly on offline analytical techniques to provide the data required to draw the necessary conclusions. HPLC has been the most commonly used analytical method due to its wide range of sample compatibility. However, HPLC as with other offline sampling techniques suffers from inherent limitations. Primarily, there is a limit to the number of samples you can take due to the significant workload associated with sample preparation and analysis. In addition, reactions under pressure or at extremely low temperature can present additional challenges in obtaining representative samples, especially if reactive or unstable components are present.

One of the biggest challenges facing the organic chemist is gaining a detailed understanding of their reactions. This can be related to a fundamental understanding of the reaction mechanism and pathway or simply knowing what components are present and how their concentrations change during the reaction. It can also be related to correlating reaction parameters to reaction performance with information such as yield, by-product formation, and reaction initiation and end-point among others being critical.

This online webinar will focus on several case studies which illustrate the complementary information the real-time in situ FTIR provides in addition to HPLC for gaining detailed insights into chemical reactions.

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Access the In Situ FTIR as a Complementary Tool to HPLC On-Demand Webinar

In situ FTIR reaction monitoring with ReactIR™ is an ideal complement to HPLC. While HPLC offers superior sensitivity for impurity profile characterization, the ReactIR™ provides real-time information about the concentrations of all major components, including reactive intermediates without the need to take samples for offline analysis. The ReactIR^TM also overcomes the sample number limitations in offline analysis, as the it is an in situ technique it can sample the reaction at one minute intervals or less providing a 'molecular video' of reaction progression. Critical information such as reaction initiation point, component concentration profiles and reaction endpoint are easily determined in real-time. Furthermore, the molecular specificity of the mid-infrared allows for a detailed understanding of reaction mechanism and pathway.

Your online presenter, Dr. Will Kowalchyk, has more than 15 years experience in the application of mid-IR and Raman spectroscopy to understanding reactive chemistry. Dr. Kowalchyk is a Technology and Application Consultant for our Reaction Analysis business.