Characterization and Optimization of Catalytic Hydrogenations on-demand webinar

Catalytic hydrogenations are industrially important processes for the introduction of functionality into pharmaceutical and agrochemical intermediates and in polyurethane chemistry. Characterization and optimization of such reactions can be particularly challenging due to the multiphase and potentially hazardous conditions that they operate under. In situ monitoring can provide a wealth of information for faster and more effective process development.

Webinar Details
Reaction calorimetry has proven to be one of the most powerful tools for kinetic and thermodynamic screening in early stages of process development. For thorough characterization of heterogeneous hydrogenation, the combination of calorimetry with IR spectroscopy and gas uptake rate measurements provide a more complete understanding. In this investigation, it is demonstrated that the kinetic information needed at early stages of chemical process design can be acquired rapidly and consistently by the complementary information provided by these three measurements.


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Different hydrogenations reactions were performed in order to demonstrate the capability and advantages of monitoring these reactions with three orthogonal measurements:
  • Heat flow trending (for determination of the heat flow profile)
  • IR spectroscopy (for the determination of concentration profiles)
  • Gas consumption (providing measurement of H2 uptake)

Simultaneous measurement of multiple signals allows deeper insight into complex reaction systems and may reveal effects that are not detectible from a single measurement signal. The fitting of kinetic models to this dynamic in situ data leads to more rapid and complete characterization of the system in question.

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