Collected Applications of Thermal Analysis
DSC Polymorphism, Sulfapyridine
The possibility of a substance exhibiting polymorphism is best investigated by first of all melting it most carefully (rapidly, under nitrogen) and then immediately shock-cooling it under its glass transition temperature (rule of thumb: Tg is roughly 3/4 Tf, both temperatures are in Kelvin). Afterwards, the different modifications can be observed by slowly heating the sample in the DSC cell.
The possibility of a substance exhibiting polymorphism is best investigated by first of all melting it most carefully (rapidly, under nitrogen) and then immediately shock-cooling it under its glass transition temperature (rule of thumb: Tg is roughly 3/4 Tf, both temperatures are in Kelvin). Afterwards, the different modifications can be observed by slowly heating the sample in the DSC cell.
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