Scale-up of crystallization is notoriously complicated and companies are under pressure to develop scalable crystallization processes faster - at lower costs and with higher quality. Companies must control crystallization conditions to improve cycle times and optimize product quality. With the incorporation of Process Analytical Technology (PAT), real-time monitoring of crystallization can be achieved without pulling samples. In situ Process Analytical Technology (PAT) tools can track critical parameters such as the crystal size and shape, the crystal form, and even the level of supersaturation.