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| On Demand Webinar | Avoiding Incidents at Scale-up: Is Your Process Resistant Towards Maloperation? |
| On Demand Webinar | Safe Process Scale-up - A Case Study of Nitroalkane Chemistry by WeylChem Presentation will show how WeylChem, a global fine chemical company specializing in custom synthesis, avoids process safety and thermal hazard analysis risks by studying heat generation. Your guest presenter, Kevin Drost, is a Senior Process Chemist at WeylChem. A scalable and cost efficient synthetic route to diformylarylbenzene was investigated. It involved a double formylation step that relies on the use of 2-nitropropane as a primary reagent. Due to the inherent energetic nature of nitroalkanes, a process safety assessment was necessary. |
| On Demand Webinar | Avoiding Batch Failures via Scale Down Simulation of Exothermic Reactions in the Lab Breakthroughs in process operations and modeling are necessary to achieve energy and material efficiency gains supporting shorter development and scale-up times while improving safety and the environmental and economical profile of chemical processes at the same time. In parts, these breakthroughs are made possible thanks to the use of Process Analytical Techniques (PAT) and reactor systems designed for real-time in situ process monitoring and accurate process control, both at lab and plant scale. In this webinar, case studies will be presented exploring the use of real time calorimetry as a process analytical tool mimicking operating conditions of industrial reactors at lab scale – to prevent batch failures at plant scale. |
| On Demand Webinar | How to Reduce Risk When Scaling-up Explosive Compounds |
| On Demand Webinar | Safe Scale-up of Chemical Processes at Chilworth |
| On Demand Webinar | Role of Process Analytical Technology (PAT) in Green Chemistry and Green Engineering Today, the chemical industry faces major challenges including globalization, environmental regulation, and shortening product life cycle. Meeting these challenges requires alternative approaches towards reducing costs and improving the environmental and economical profile of chemical processes. Breakthroughs in process operations and process modeling have been necessary for achieving energy and material efficiency gains. These breakthroughs allow real time in situ process monitoring, characterization, and accurate control. |
| On Demand Webinar | 20 Years of Reaction Calorimetry at Johnson and Johnson Learn how Johnson and Johnson avoids chemical reaction hazards using reaction calorimetry. |
| On Demand Webinar | The Importance of Mixing: How to Compare Lab Scale Mixing with Full Scale Process Vessel Performance Process objectives are critical for successful manufacturing of a product. If the mixing scale-up fails the required yield, quality, or physical properties of the product and the costs of manufacturing may be significantly increased . Failure to provide the necessary mixing may result in severe manufacturing problems on scale-up, ranging from costly corrections in the plant to complete failure of a process. The costs associated with these problems are far greater than the cost of adequately evaluating and solving the mixing issues during process development. Conversely, the economic potential of improved mixing performance is substantial. Therefore, at the heart of any scale-up chemical process, there has to be a fundamental understanding of how the mixing processes in a lab reactor compares to the mixing performance of a full scale process vessel which is targeted to receive the lab developed process. |
| On Demand Webinar | New Developments in the Use of PAT and Laboratory Automation from the Pharmaceutical and Chemical Industries |