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|On Demand Webinar|| Hydrogenation and High Pressure Reaction Monitoring |
This presentation discusses the implementation of Fourier Transform Infrared (FTIR) reaction monitoring technology to provide knowledge and understanding about key reaction parameters that enabled successful hydrogenation.
|On Demand Webinar|| Monitoring Cell Count, Size and Shape in Fermentation Processes |
Fermentation process monitoring including E. Coli, mammalian cells, plant cells and filamentous organisms are discussed in this webinar
|On Demand Webinar|| Highly Reactive Chemistry: Minimize Hazard and Risk |
Case studies are presented illustrating how to ensure safe development, scale-up and operation of highly reactive chemistry.
|On Demand Webinar|| Optimizing Flow Assurance and Separations in the Petroleum Industry |
This webinar focuses on case studies from the Petroleum Industry where flow assurance and separations have been optimized.
|On Demand Webinar|| Optimization of High Shear Wet Granulation |
This webinar discusses how to quantify the effect of critical process parameters during the high shear wet granulation process to target a specific growth profile, wet massing time, and endpoint particle size and shape distribution with various placebo and API formulations.
|On Demand Webinar|| Reducing the Risk of Highly Reactive Chemistry in Chemical R&D Part 2 |
Case studies are presented illustrating how to aid in the safe development, scale-up and operation of highly reactive chemistry.
|On Demand Webinar|| Supersaturation Monitoring and Control during Crystallization |
Learn how to address problems in your crystallization processes with supersaturation. Part 1 of this webinar series focuses on supersaturation monitoring during crystallization.
|On Demand Webinar|| Top Five Ways To Improve Laboratory Crystallization |
This webinar discusses five ways to identify ideal crystallization conditions in the laboratory. Key stages in the process development lifecycle where laboratory crystallization has been improved are included.
|On Demand Webinar|| Process Analytical Technology (PAT): The “Official” Language of Pharmaceutical Outsourcing |
The application of Process Analytical Technology (PAT) to improve pharmaceutical outsourcing communication is discussed.
|On Demand Webinar|| In Situ Monitoring of Chemical Reactions - Recent Advances in Organic Chemistry Part 3 |
In situ Fourier Transform Infrared (FTIR) provides real-time monitoring of chemical reactions and is suitable for a wide range of chemistries and applications. This presentation demonstrates how ReactIR™ supports the fundamental understanding of organic chemistry and enables chemical engineering research.
|On Demand Webinar|| Metal Detection, X-ray Inspection or Both: Making the Right Choice |
The choice of an inspection system for your production line may seem confusing, perhaps even daunting. Adding to this are widely held misconceptions about the capabilities and operation of the two major inline product inspection technologies – metal detection and x-ray inspection.
|On Demand Webinar|| X-ray or Checkweighers – Checking for mass or weight: making the right choice |
Weight & Mass are often used as interchangeable terms in todays product inspection arena. In most applications the preferred choice for weight determination is through the use of a scale which in packaging processes takes the form of an in-line checkweigher using gravity and mass to determine an accurate weight value.
|On Demand Webinar|| High Performance Checkweighing for Maximum OEE |
Today’s business environment demands performance measurements not only to long term financial investment goals but also against day-to-day, shift-to-shift, and hour-by-hour production targets. For nearly 20 years, many production companies have used Overall Equipment Effectiveness (or OEE for short) as an internal measurement of production line efficiency.
|On Demand Webinar|| Reducing Time to Manufacturing Using Real-time In Situ FTIR Analytics as a PAT Tool |
The use of real-time in situ mid-infared (mid-IR) analytics as a Process Analytical Technology (PAT) tool early in process development has become widespread particularly in the pharmaceutical industry in order to run information rich experiments which results in shorter project timelines. Not only does this result in meeting Quality by Design (QbD) objectives, but it also results in the ability to move processes to the manufacturing environment faster.
|On Demand Webinar|| Roller Compaction Process Optimization Using At-Line Particle Characterization |
One goal of roller compaction is to improve compressibility and yield repeatable tablet dissolution and content uniformity. To ensure downstream process and product consistency, a successful roller compaction process establishes a continuous flow with a consistent particle size distribution. However, inconsistencies often occur during dry granulation scale-up due to changing raw materials or process dynamics such as segregation, compaction force, and flow properties.
|On Demand Webinar|| Simplify Process Characterization by Combining Thermal Data with In Situ IR Spectroscopy |
The capabilities and advantages of monitoring kinetics using online infrared (IR) techniques in combination with precisely controlled synthesis workstations or reaction calorimeters is presented using different reactions.
|On Demand Webinar|| Application of Quantitative Analysis to Predict Absolute Concentration Information in Real-time |
Relative concentration is sufficient for reaction progression information such as initiation, intermediate formation and endpoint. However, the ability to predict absolute concentration in real-time is sometimes desired or essential, especially during production monitoring, and for monitoring and controlling continuous processes. Part IV discusses the application of quantitative analysis using real-time in situ FTIR focusing on strategies that produce the best quantitative results for the desired outcome. Software tools for quantitative method evaluation will also be covered. This is Part IV of the webinar series - Introduction to Real-time In Situ FTIR for Rapid Reaction Progression Determination and Reaction Characterization.
|On Demand Webinar|| Innovative Approaches for the Synthesis and Purification of Peptide Libraries |
Peptide libraries are widely investigated and routinely screened for their drug-like properties. Synthesis using resins or solid supports is a favorite route for researchers performing peptide synthesis. However, synthesis and subsequent purification are major bottlenecks encountered during synthesis of peptide libraries. This webinar examines challenges related to the synthesis of peptide libraries and will discuss various applications including the synthesis of cyclic peptides employing a unique safety-catch linker, which enables the production of diverse libraries for biological screening.
|On Demand Webinar|| iC Quant™: What are Factors and How Are They Used in Quantitative and Discriminate Analysis? |
|On Demand Webinar|| Use of PAT and Laboratory Automation from the Pharmaceutical & Chemical Industries - New Developments |
Intergration of process analyzers and process automation together with the use of multivariate tools for design, data acquisition and analysis is critical and listed in Food and Drug Administration (FDA) guidance of Process Analytical Technology (PAT). Their use helps conduct information-rich experiments that respond to the need for increased process development throughput, downstream consistency and reliability.
|On Demand Webinar|| Introduction to Reaction Analysis Using Real-Time In Situ FTIR |
This webinar introduces the use of Fourier Transform Infrared Spectroscopy (FTIR) for reaction analysis and monitoring, and includes a comparison to other well known spectroscopic techniques. The method of measurement and probe and sensor options available will be discussed as well as best practices on how to collect high quality data that will facilitate easy interpretation.
|On Demand Webinar|| The Importance of Mixing: How to Compare Lab Scale Mixing with Full Scale Process Vessel Performance |
Process objectives are critical for successful manufacturing of a product. If the mixing scale-up fails the required yield, quality, or physical properties of the product and the costs of manufacturing may be significantly increased . Failure to provide the necessary mixing may result in severe manufacturing problems on scale-up, ranging from costly corrections in the plant to complete failure of a process. The costs associated with these problems are far greater than the cost of adequately evaluating and solving the mixing issues during process development. Conversely, the economic potential of improved mixing performance is substantial. Therefore, at the heart of any scale-up chemical process, there has to be a fundamental understanding of how the mixing processes in a lab reactor compares to the mixing performance of a full scale process vessel which is targeted to receive the lab developed process.
|On Demand Webinar|| Calibration Free Supersaturation Assessment and Control for the Development and Optimization of Crystallization Processes |
The quantitative use of in situ ATR-FTIR for real time supersaturation assessment has been extremely well defined within the literature. However, these now well structured and understood methodologies have yet to be incorporated into the standard pharmaceutical crystallization development due to time and calibration/statistical analysis experience. In this webinar, a method will be presented which facilitates the calibration free use of in situ ATR-FTIR spectra for the production and control of qualitative supersaturation trajectories.
|On Demand Webinar|| 20 Years of Reaction Calorimetry at Johnson and Johnson |
Learn how Johnson and Johnson avoids chemical reaction hazards using reaction calorimetry.
|On Demand Webinar|| In Situ Flow Technology to Continuous Processing - Part I |
The ReactIR™ flow cell is presented as a convenient inline analytical tool for continuous flow chemistry processing. The flow cell, operated with ATR technology, is attached inline using standard Omnifit® connections. With the established iC IR 4.0 software the consumption of reagents and formation of products can be monitored in real-time, allowing for rapid optimization. Unstable reactive intermediates can also be observed in situ, giving mechanistic insight to complex transformations.