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Date | Alphabetical
| Delivering Robust Processes for Production Environments |
| Understand and Control Process Chemistry |
| New Experimental Techniques for Organic Synthesis The white paper - Chemical Synthesis Beyond the Round Bottom Flask - discusses how newly developed methodologies for chemical syntheses are eliminating key challenges, and introduces the concept of chemical synthesis without the traditional round bottom flask. |
| Understand and Optimize Flow Assurance, Emulsions, and Drilling Mud Applications Multiphase pipeline flow often occurs under extreme temperature and pressure conditions making offline sampling and analysis difficult or impossible. Offline samples are often manipulated through dilution or dispersion which alters or destroys multiphase components. Offline measurements cannot be applied to make real-time process optimization and control decisions. |
| Effortless Flow Chemistry Knowing immediately if the chemistry is at steady state, converting to the desired product, etc., is essential information when developing a robust process in the shortest possible time. FlowIR™ can be interfaced to any continuous flow reactor system and placed virtually anywhere in the fume hood, where space is precious, ensuring the system is easy to use. Being able to monitor the chemistry in situ ensures the collection of the best possible reaction information, which is typically not the case for conventional offline measurement methods. In addition, not having to extract samples increases personnel safety when dealing with highly toxic, energetic or unstable materials. |
| Best Practices for Crystallization Development White Paper The latest whitepaper – Best Practices for Crystallization Development: A Review of Modern Techniques – demonstrates the methodology used to quickly understand crystal growth, nucleation, size, and shape from within the crystallizer and optimize critical parameters such as the temperature profile, addition rates, and seeding to improve purity, filtration rates, and batch repeatability. |
| Organic Synthesis Performed Easier The OptiMax™ synthesis workstation redefines the way organic chemistry is performed offering simple accurate and reproducible operation. OptiMax™ eliminates the need for round-bottom flasks, oil and ice baths, heating mantles and bulky cryostats. Intuitive operation simplifies the control of experiments, which can be left to run unattended. |
| Robust Processes Thanks to Early Hazard Identification EasyMax™ was designed to meet the challenges of today’s synthetic chemist. Designed as a replacement for the round bottom flask, EasyMax™ is a personal chemistry workstation which eliminates the need to use heating mantles, oil baths, ice baths and cryostats. With no training requirement, EasyMax™ is fast and easy to set up, making users immediately productive. The data logging capabilities of the system capture experimental data which delivers an enhanced understanding of the reaction under investigation, leading to faster reaction optimization and characterization. When used in early stage process development, EasyMax™ delivers key insight to chemists regarding key reaction events. As multiple experiments are completed, EasyMax™ gives the chemist a reproducible ‘chemical rate meter’ in every experiment. |
| Investigate Chemical Processes Safely Understanding a chemical process in detail significantly reduces the risk of failures at large scale. With RTCal™ real time calorimetry the heat release of a process is measured in real time allowing the ideal dosing profile to be set. Data collected is converted with iC Safety™ software into relevant safety information to automatically assess the thermal risk of a reaction. |
| Investigate C-H Functionalization with In Situ FTIR The past two decades has seen an explosive growth in the development of methods for C-H functionalization. These methodologies provide a wide range of very useful techniques for the synthesis of a diverse range of complex targets, such as natural products and active pharmaceutical ingredients. |
| Fast, Easy and Real-Time Particle Analysis Focused Beam Reflectance Measurement (FBRM®) provides the unique measurement of particles and droplets in concentrated suspensions and emulsions. The latest generation of FBRM technology is robust, versatile and ideal for the processing environment. A new design makes it even easier to characterize particles and understand flocculation. |
| Recent Advances in Organic Chemistry - Metal Catalysed Transformations Chemical transformations, catalyzed by transition metals, play an important role in the field of catalysis. This white paper, ‘Recent Advances in Organic Chemistry – Metal Catalyzed Transformations’, looks at some of the latest research published in this area. |
| Best Practices for QbD Experiments Quality by Design (QbD) consists of rapidly changing process and product development methods used throughout the pharmaceutical industry. QbD studies require the highest quality of experimental equipment and Process Analytical Technology (PAT) to ensure an accurate determination of process variability and maximum confidence in the proposed design space. |
| Improve Flocculation Product Quality When separating solids from a liquid, flocculation is used to maximize the rate and degree of separation. In the paper industry, flocculation is used to maximize production throughput and product quality. Regardless of the process, these goals need to be met by using the least amount of chemicals possible as well as meeting quality assurance requirements. By maximizing throughput, the scale of equipment needed can be reduced, which is especially important with gravity thickeners when conducting flocculation for mining or wastewater. |
| Incredible ReactIR 4000 Trade-In Promotion Do you have a ReactIR™ 4000 that needs upgrading? METTLER TOLEDO has an offer for you. As a discontinued product, the ReactIR™ 4000 system is no longer available and the support period for your instrument will soon end. Trade-in your ReactIR™ 4000 today and save 15% on a replacement ReactIR™ 45m or ReactIR™ 15 unit. |
| Breakthrough Performance for Inline Particle Measurement The next generation FBRM® has been completely redesigned making it significantly easier to get even more information out of each experiment. This latest FBRM® technology, found in the FBRM® G400 and FBRM® G600 models, establishes a new standard for inline measurement of particles, crystals and droplets – improving the accuracy and resolution of the measurement while making the data easier to understand. |
| Reduce Explosive Compound Scaling-up Risks Challenges exist during the development and scale-up of highly energetic materials. In addition to achieving the desired yield, purity, and particle size distribution, process safety issues associated with explosive compounds must also be addressed. Risks can be reduced or eliminated by using reaction calorimetry and in situ FTIR reaction monitoring. |
| Simple and Cost Effective Reaction Process Monitoring Whether challenged by space constraints and/or complex installation requirements, ReactIR™ 247 is a unique process-hardened FTIR spectrometer designed to fit into nearly any space without sacrificing the proven performance of ReactIR™ technology. Designed for classified environments, it is engineered to be simple to use, highly compact, cost effective and have the overall performance required for reaction and process monitoring in kilo labs, pilot plants, hydrogenation labs and production facilities. |
| A New Approach to Productivity: Synthesis Made Easy EasyMax™ is a future-oriented personal synthesis workstation, replacing the traditional round-bottom flask. It is simple to use, efficient, safe and requires no cryostat, no PC and only minimal space in the fumehood. EasyMax™ increases productivity in chemical development thanks to higher quality experiments of each single experiment. |
| White Paper: Process Analytical Technology (PAT) for Biotech |
| Combine The Benefits of Flow Chemistry and Online Analysis Take advantage of the combination of flow hydrogenation reactions and real time reaction analysis to deliver a faster way to perform and optimize hydrogenation reactions and receive a 20% discount on one or both of these technologies – available for a limited time only.* |
| Effective Flocculation Leads to a Better Process Throughput Flocculation performance in polymers and chemicals depends on the incoming particle size distribution, solids concentration, mixing efficiency, additive type and dosage. Flocculation effectiveness influences downstream separation, settling, flotation, and purification. |
| Optimize and Troubleshoot Crystallization With Process Analytical Technology (PAT) |
| Improve Continuous Process Production With Real-Time Reaction Monitoring and Flow Synthesis ThalesNano and METTLER TOLEDO announced a collaboration to combine their existing technologies to offer flow reactor technology with real time reaction monitoring for faster reaction optimization and improved continuous process production. The customer-driven collaboration will result in the integration of ThalesNano’s entire flow reactor line with the METTLER TOLEDO ReactIR DS Micro Flow Cell system to take flow chemistry beyond where it is today. |
| Improve Chemistry Understanding with Reaction Analysis METTLER TOLEDO announced the release of the ReactIR™ 15 reaction analysis and reaction monitoring system. ReactIR™ 15 is a Fourier Transform Infrared Monitoring (FTIR) instrument that is ideally suited for general, in situ reaction analysis understanding. Progressive technology and software allow this ReactIR™ to be used effortlessly by any chemist, whether skilled in spectroscopy or not. |