Applications

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Reducing your Risks: Optimization of Highly Reactive Chemistry

Brochure: Advanced Crystallization Development Improving yield, throughput, and crystal purityCrystallization is often a critical processing step in the isolation of intermediates and the final product. Advanced Crystallization development, using in-process Process Analytical Technologies (PAT), enables you to:

Selective Chlorination Chlorinations are common processes for producing intermediates and active ingredients in the agricultural, pharmaceutical, and fine chemical industries. The ability to detemine the chlorine substitution position and the relative degree is critical to formation of the desired product as well as to control the formation of side products. Selectivity and yield of the reaction can be optimized by timely endpoint determination.

Amide Synthesis via a Reactive Acid Chloride Intermediate

In-Process Characterization of Antisolvent Crystallization

Rosenmund Reduction Gain insights into difficult chemistryGain insights into successful scale-up when reaction conditions and unstable intermediates prohibit or complicate extractive sampling and offline measurements.

Reductive amination scale-up Enhance understanding of difficult chemistry with in situ IR productsGain insights into successful scale-up when reaction conditions and unstable intermediates prohibit or complicate extractive sampling and offline measurements.

Use of Process Analytical Technology (PAT) in multipurpose API plants - Pfizer Process Analytical Support Group Dave Sharp, API Development Team, Pfizer Process Analytical Support Group

Controlling Particle Size and Polymorph Form in Active Pharmaceutical Ingredients (API) Production Adam J. Fine, Kevin D. Seibert, and Jean W. Tom, Merck & Co., Inc.

Online Monitoring of Crystallization of a Polymorphic Compound Using FBRM®, PVM®, and Raman A.T. Andrews, P. Fernandez, M. Midler, R. Osifchin, S. Patel, Y.-K. Sun, H.H. Tung, J. Wang, and G.X. Zhou, Merck & Co., Inc.

Implementation of an online technique for continuous processing - Bristol-Myers Squibb Company Mourad Hamedi, Bristol-Myers Squibb

Using ReactIR in Chemical Development - GlaxoSmithKline Bob Cooley, GlaxoSmithKline

Nitrobenzyl reduction Gain insights into difficult chemistryGain insights into reaction performance and variableswhen conditions prohibit or complicate extractive sampling and offline measurements.

Supersaturation monitoring with ReactIR ATR-FTIR

ReactIR™ in situ reaction analysis applications brochure Nitrobenzene Hydrogenation, Chiral Hydrogenation of a Carboxylic Acid, Grignard Reagent, Formation of Chiral Ester via Alcoholysis of a Ketene

The Challenges of Modeling and Scaling-up a Solid/Solution Reaction Sean P. Lapekas and Donald J. Knoechel, Pharmacia Corporation, Kamalazoo, MI, USA.

Reaction Kinetic Studies Using a Pulse-Feed MP10 Pressure Reactor with ReactIR Joseph Chan, DuPont Co., Wilmington, USA.

Monitoring Crystallization Processes Using MultiMaxIR™ and ReactIR™ - Schering-Plough Research Institute Vijay Sabesan and Vince Liotta, Schering-Plough Research Institute, USA.

Use of Automated Batch Laboratory Reactor Systems other than the RC1 in Process Development and Scale-up James T. Leach, Eastman Chemical Company, USA.

In situ Infrared Spectroscopy for Green Process Design István T. Horváth, Department of Chemical Technology and Environmental ChemistryEötvös University, Budapest (Hungary) & Molecularis, Princeton, New Jersey (USA).

Optimization of a Hazardous Reaction with Strong Gas Release-Online-Monitoring in Solution and Gas Phase by Using ReactIR Kai Lovis, Schering AG, Berlin (Germany).

A Study of the Role of EDCI/HOBt (carboiimide coupling reagents) in Amide Bond Formation by Microcalorimetry and by ReactIR Lai Chun Chan, AstraZeneca R&D (UK).

«Stealth Engineering» – the Secret Life of a Process Safety Engineer Sean Lapekas, Pfizer Ltd Global R&D (USA).

Real-time in situ FTIR analysis of liquid phase catalytic reactions

ReactIR in situ FTIR monitoring of API manufacturing unit operations - Pfizer, Inc.