This online seminar review the application of in situ process analytical tools for improving crystallization product size, yield, and purity. Specific examples include crystallization of 3-nitro-1,2,4-triazole-5-one (NTO), cyclotetramethylene tetranitramine (HMX), and guanidinium azaotetrazolate (GuZT). Crystallization is a critical separation and purification technique in the energetic materials industry. End product qualities such as burn rate, flow property, packing density, and formulation are tightly linked to the crystal size distribution and crystal shape. In addition, process efficiency such as filtration, washing and drying are a function of the crystallization and end point particle size distribution (PSD). Optimizing and controlling crystallization batch repeatability are achieved by an understanding of crystal nucleation, growth, agglomeration, and breakage. Focused Brea Reflectance Measurement (FBRM®) and Particle Vision Microscope (PVM®) are inline probe-based tools to track changes to particle dimention, shape, and count in real time without pulling samples. |  Preview the On-Demand Webinar |