METTLER TOLEDO
 

Roller Compaction Process Optimization Using At-Line Particle Characterization

One goal of roller compaction is to improve compressibility and yield repeatable tablet dissolution and content uniformity. To ensure downstream process and product consistency, a successful roller compaction process establishes a continuous flow with a consistent particle size distribution. However, inconsistencies often occur during dry granulation scale-up due to changing raw materials or process dynamics such as segregation, compaction force, and flow properties.
Des O'Grady
English

In this webinar, the application of in situ particle characterization is demonstrated to map the design space and optimize a series of roller compaction runs while varying raw materials, flow rates, and roller compaction forces.

As was presented at the AAPS (American Association of Pharmaceutical Scientists) Annual Meeting 2009: in situ particle characterization allows formulators or engineers to detect process upsets such as segregation and directly link process control parameters to the particle distribution. This enables formulators to ensure consistent product performance. By designing a robust roller compaction process, formulators and engineers can ensure consistent downstream processing from dry granulation through tablet compression.

Related topics: roller compaction, particle size, particle characterization, dry granulation, particle size, Process Analytical Technology, PAT, QbD, Quality by Design, control roller compaction, tablet dissolution, AAPS, American Association of Pharmaceutical Scientists, Lasentec, formulators, formulation, formulations