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Jun 21, 2009 - Jun 24, 2009 Washington State Convention and Trade Center Seattle, WA USA |
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| Contact METTLER TOLEDO |
The 2009 National Biotechnology Conference features plenary sessions, symposia, roundtable discussions, poster sessions and an exposition. METTLER TOLEDO is pleased to be attending this event.
The Role of Particle Morphology in Biotechnology
Particle morphology is an important parameter in both upstream and downstream large-scale bioprocessing operations. In the cultivation of filamentous organisms, both the size and structure of mycelial entities can significantly impact product formation and fermentation performance. In the downstream extraction and purification of biological products, both product recovery rate and process efficiency are highly dependent on the nature of the dispersed phase, which is typically present in all such operations.
The Role of Particle Morphology in Biotechnology
Particle morphology is an important parameter in both upstream and downstream large-scale bioprocessing operations. In the cultivation of filamentous organisms, both the size and structure of mycelial entities can significantly impact product formation and fermentation performance. In the downstream extraction and purification of biological products, both product recovery rate and process efficiency are highly dependent on the nature of the dispersed phase, which is typically present in all such operations.
In Situ Monitoring of Biological Systems Using FBRM®
Rapid and reliable scale-up is essential for cost-effective bioprocess development, but a key issue in development of scale-up strategies is the identification and monitoring of scale-dependent process variables.
In this study, the bioprocesses of particular interest are filamentous fermentations and plant cell suspension cultures. For filamentous micro-organisms, which are prolific producers of bioactive products, growth and morphology are among the most important process variables. The same is true for plant cell suspension cultures - potential sources of multiple, complex natural agents.
Rapid and reliable scale-up is essential for cost-effective bioprocess development, but a key issue in development of scale-up strategies is the identification and monitoring of scale-dependent process variables.
In this study, the bioprocesses of particular interest are filamentous fermentations and plant cell suspension cultures. For filamentous micro-organisms, which are prolific producers of bioactive products, growth and morphology are among the most important process variables. The same is true for plant cell suspension cultures - potential sources of multiple, complex natural agents.
FBRM® (Focused Beam Reflectance Measurement) Technology
Over twenty years ago, FBRM® technology was pioneered and patented by former Lasentec® scientists and engineers. FBRM® evolved into a probe-based technology providing a fast and sensitive method of tracking the rate and degree of change in particles and particle structures as they actually exist in process.FBRM® technology is designed to provide in-process particle system characterization in real time. METTLER TOLEDO continually researches and improves FBRM® technology - pushing the boundaries of in-process measurement of high concentration slurries and particle systems.
Over twenty years ago, FBRM® technology was pioneered and patented by former Lasentec® scientists and engineers. FBRM® evolved into a probe-based technology providing a fast and sensitive method of tracking the rate and degree of change in particles and particle structures as they actually exist in process.FBRM® technology is designed to provide in-process particle system characterization in real time. METTLER TOLEDO continually researches and improves FBRM® technology - pushing the boundaries of in-process measurement of high concentration slurries and particle systems.