Webinars - METTLER TOLEDO

Webinars

The Importance of Mixing: How to Compare Lab Scale Mixing with Full Scale Process Vessel Performance

06/04/08 - 9am US EDT
06/04/08 - 2pm US EDT

Process objectives are critical for successful manufacturing of a product. If the mixing scale-up fails the required yield, quality, or physical properties of the product and the costs of manufacturing may be significantly increased . Failure to provide the necessary mixing may result in severe manufacturing problems on scale-up, ranging from costly corrections in the plant to complete failure of a process. The costs associated with these problems are far greater than the cost of adequately evaluating and solving the mixing issues during process development. Conversely, the economic potential of improved mixing performance is substantial. Therefore at the heart of any scale-up chemical process has to be a fundamental understanding of how the mixing processes in a lab reactor compares to the mixing performance of a full scale process vessel which is targeted to receive the lab developed process.

This webinar will provide you with best practices to solve mixing issues and will highlight both practical and theoretical aspects.

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Building an Effective Metal Contamination Detection Program

06/25/08 - 2pm US EDT

In today’s increasingly competitive marketplace, consumers point to safety as their number one food supply concern and the need to operate an effective metal detection program has never been more essential. Led by Mettler-Toledo Safeline experts in metal detection technology, this 1½ hour webinar will cover the basic principles of metal detection through to the implementation of a comprehensive program. A distinguished customer panel will also provide real-world insights on best practices. All registered attendees will also receive a complimentary copy of “Reduction of Metal Detection – Building an Effective Program”, the newly published, 63-page definitive industry guide for all those involved in understanding and implementing metal detection technology. More information ...

Tools for Successful Crystallization in the Pilot Plant and Production

06/25/08 - 9am US EDT
06/25/08 - 2pm US EDT

Crystallization processes designed at small scale regularly behave completely differently when scaled initially to pilot plant, and finally to full scale commercial production. This scale up can create significant changes in critical particle properties such as the crystal size, shape, purity and polymorphic form, subsequently impacting the downstream operations. Lasentec^® technology has established itself as a fundamental requirement for the optimization of such large scale crystallization processes.

The pilot plant is vital in achieving key objectives such as process development, clinical supply manufacture, scale up and transfer. Information on the crystallization step at this stage can decrease the development time required in the pilot plant while subsequently gaining a valuable insight into the impact of scale up on the process.

At production scale it is important to ensure that the process is robust and reproducible there-by ensuring consistency from batch to batch. The process can also be optimized even further at this scale to improve filtration and drying times while controlling the particle size to the desired specification.

In this webinar we will introduce and discuss real cases from industrial users. Topics to be discussed include:

Optimization of the particle size
Improving filtration rates
Optimization of drying times
Optimization of yield
Ensuring batch to batch consistency
Assessing the impact of mixing on scale up

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